PROTAC (Proteolysis-Targeting Chimera), protein hydrolysis targeting chimeras, which use the ubiquitin-protease
system to target specific proteins for intracellular degradation, have become an emerging drug modality that has
been rapidly developed in recent years.
The PROTAC molecule consists of a target protein ligand (POI
ligand), a linker, and an E3 ligand, which specifically binds the target protein while recruiting E3 ligase.
The E3 ligases commonly used in PROTAC are MDM2, cIAP1, VHL and CRBN, and VHL and CRBN are the main
ones used in the current study.
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