Publications|ReadCrystal-Your Exclusive Expert In Structure Determination-Structural Biology-X-Ray Crystallography-CryoEM-SPA-MicroED-Drug Discovery

Accurate structure determination of nanocrystals by continuous precession electron diffraction tomography

Sci. China Mater. 2022, 65(5), 1417–1420. doi:10.1007/s40843-021-1941-6

This study introduces a novel three-dimensional electron diffraction method (cPEDT) combining continuous rotation with electron beam precession for the accurate determination of atomic structures of electron-beam-sensitive nanocrystalline materials (such as MOFs, COFs, and organic compounds).

ReadCrystal was responsible for the cPEDT data collection of the electron-beam-sensitive organic compounds. Using our advanced electron diffraction technology platform, we assisted in successfully acquiring high-quality three-dimensional diffraction data.

Crystalline Sponge Method by Three-Dimensional Electron Diffraction

Front. Mol. Biosci. 2022 Feb 7;8:821927. doi: 10.3389/fmolb.2021.821927.

This study demonstrates the implementation of the nanocrystalline sponge method using three-dimensional electron diffraction (3D-ED/MicroED) technology, successfully determining the precise structures and occupancies of guest molecules (such as nitrobenzene and guaiazulene) adsorbed within the nanoporous coordination complex crystals.

ReadCrystal was responsible for the 3D-ED data collection and processing of the nanocrystalline sponge crystals. Using our in-house developed Heimdall data collection software and Coeus data processing platform, we successfully solved the fine structures of both the host framework and the guest molecules.

Structural origin of the high-voltage instability of lithium cobalt oxide

Nat Nanotechnol . 2021 May;16(5):599-605. doi: 10.1038/s41565-021-00855-x.

This paper reported structural differences at the atomistic level between two commercial LCO materials: a normal LCO (N-LCO) and a H-LCO.

Structure determination of LCO was done by the team of Prof. Junliang Sun, the founder of ReadCrystal. Three-dimensional continuous rotation electron diffraction method was used to determine the structure, also called MicroED.

Atomically precise single-crystal structures of electrically conducting 2D metal-organic frameworks

Nat Mater . 2021 Feb;20(2):222-228. doi: 10.1038/s41563-020-00847-7.

This paper reported crystal structures of 2D π-conjugated MOFs with electrical conductivity, and the atomic-level resolution structures were precisely determined by the cultivation of large single crystals and MicroED techniques.

Structure determination of MicroED in this paper was done by the team of Prof. Junliang Sun, the founder of ReadCrystal.

Structural basis of Gs and Gi recognition by the human glucagon receptor

Science . 2020 Mar 20;367(6484):1346-1352. doi: 10.1126/science.aaz5346.

This paper reported the structures of the human glucagon receptor (GCGR) bound to glucagon and distinct classes of heterotrimeric G proteins, Gs or Gi1 which were determined by Cryo-EM SPA.

The researcher who was responsible for the structure determination of GCGR by Cryo-EM SPA in this paper is currently working at ReadCrystal, in charge of the Cryo-EM SPA project.

Single crystal of a one-dimensional metallo-covalent organic framework

Nat Commun . 2020 Mar 18;11(1):1434. doi: 10.1038/s41467-020-15281-1.

In this paper, a single crystal of mCOF was synthesized and its structure was determined by MicroED technique.

Structure determination of MicroED in this paper was done by the team of Prof. Junliang Sun, the founder of ReadCrystal.