|
Case Study |
|
|
Target |
Menin |
|
Small molecule modulator |
≤300 |
|
Screening method |
SPR (Biacore 8K)+Soaking |
|
Fragments screened |
2700 |
|
Initial binding hits 108 (4%) |
108 (4%) |
|
Confirmed hits with affinity (KD) better than 200 μM |
35 (1.3%) |
|
Crystal screening to obtain cocrystals and structure determination to confirm ligand binding |
15 (0.6%) |
