|
Case Study |
|
|
Target |
METTL3 |
|
Screening method |
FRET (EnVision 2105) |
|
Fragments screened |
3000 |
|
Initial binding hits 23 (1.3%) |
23 (1.3%) |
|
Confirmed hits with affinity (KD) better than 200 μM |
6 (0.35%) |
System establishment Enzyme activity screening